Nurx PrEP Daily Pill: Up to 99% Effective at Preventing HIV?

Nurx PrEP Daily Pill

What is PrEP?

PrEP (Pre-exposure Prophylaxis) is for people who are not living with HIV and would like to remain HIV-negative and is a combination of safe sex practices and a daily medication.

Currently, the only FDA approved medication for PrEP is Truvada®. It was approved for HIV prevention in 2012 and contains two medications: tenofovir and emtricitabine.

Pre = before
Exposure = coming into contact with HIV
Prophylaxis = treatment to prevent an infection from happening

Think of it like this: Truvada® for PrEP is like birth control. You take a pill every day, and if you are exposed to HIV, there is a 99% chance that you stay negative for HIV!

Just like women who take birth control pills every day and have sex without getting pregnant.

What are they saying?


Protect yourself, protect your partners. PrEP is a daily pill for people who do not have HIV and are looking to stay HIV negative.


Truvada for PrEP (Pre-exposure Prophylaxis) is a daily pill that is up to 99% effective at preventing HIV.


  • Up to 99% effective
  • Not for those already living with HIV
  • Affordable options with or without insurance
  • Requires quarterly HIV/STI testing
  • Three month supply of Truvada per order


PrEP is only for people who are currently not living with HIV. So, in order to get your prescription, you’ll need to first be screened for HIV/STIs. And, to stay on PrEP, you’ll need to be screened every three months.


Truvada isn’t cheap. Thankfully, there are payment assistance programs that can make it affordable. Whether or not you have insurance, we’ll help you take advantage of available discounts.


1. Tell us about yourself.

Answer a few health questions. If you are eligible for PrEP, our partner lab will mail you a HIV/STI testing kit in a discreet package.

2. Self-test at home.

Collect your samples as instructed and mail them back to the lab for screening, using the box and prepaid label included in the kit.

3. Our doctors review.

Based on your lab results, one of our medical providers will decide whether PrEP is the right choice for you.

4. We prescribe PrEP.

We’ll send you a three month supply of daily pills. To safely continue taking PrEP you need lab tests every three months.

5. Repeat on schedule.

Before your three month supply runs low our partner lab will mail you another HIV/STI testing kit. Just send it in to continue on PrEP.

Why Nurx?

We believe that control over our own sexual health is a fundamental right. So we make it as simple and affordable as accessing any preventative medicine. Your body. Your choice. It’s that simple.


How much does PrEP cost?

PrEP is expensive, but it doesn’t necessarily mean you should have to pay for all of it. Often PrEP is covered by insurance, Medicaid, and Medicare.

Payment assistance programs are available to help with co-pays or high deductibles. Depending on your insurance coverage, we recommend that you take some time to apply to any payment assistance program(s) you qualify for.

Unfortunately, these programs do not cover the cost of lab work and Nurx cannot cover the cost of labs for you.

You’ll be responsible for the full cost of the labs to get started on PrEP. The home testing kits are $25 plus any insurance co-pays or deductibles, or (if you don’t have insurance) a flat rate of $129 for the Basic kit and $199 for the Comprehensive.

If you are visiting a physical lab location, always check on the cost at the lab before you complete any tests.

What are the side effects of PrEP?

Many new PrEP users report little to no side effects, but symptoms such as headache, abdominal pain, and weight loss can happen.

These side effects typically don’t last long and often go away entirely within the first month. If you’re experiencing prolonged side effects, please contact us.

What if I miss a dose of PrEP?

If you miss a dose or skip a day, it’s ok! Take your pill as soon as you remember and continue with your daily schedule.

Do not double dose, as you may feel nauseous or sick. Missing one dose won’t greatly affect your level of protection against HIV.

However, if you are missing multiple days or are having trouble with taking a pill daily, let us know.

What is the difference between PrEP and PEP?

If PrEP is like birth control, then PEP is like emergency contraception.

PEP (Post-exposure Prophylaxis) is a medication regimen someone who is currently HIV-negative can take to reduce their risk of becoming infected after they have been exposed to HIV.

PEP must be started within 72 hours after a possible exposure and continued for 28 days. If you feel you may need PEP, please visit your local emergency room or urgent care.

Post = after
Exposure = coming into contact with HIV
Prophylaxis = treatment to prevent an infection from happening

How effective is PrEP?

Truvada® for PrEP is highly effective at preventing HIV when taken as prescribed. Studies have shown that PrEP reduces the risk of getting HIV through sexual activity by up to 99% and by more than 70% among people who inject drugs.

How does PrEP work?

Truvada® for PrEP works by blocking an enzyme called HIV reverse transcriptase. By blocking this enzyme, it prevents HIV from making more copies of itself in the body. You will remain HIV negative if the virus can’t make enough copies of itself in your system.

How long do I need to take PrEP?

You take Truvada® for PrEP as long as you are at risk for contracting HIV. For some people, this can mean for the duration of a relationship, and for others, this can mean for a lifetime.

PrEP is something that you can start and stop at any time without long-term side effects. PrEP should be continued for 30 days after the last potential exposure to HIV.

Each time you start Truvada® you will need to take it for 7 to 21 days before it reaches maximum effectiveness.

If you are considering stopping PrEP, please contact our medical team and we’ll help advise you so you can stop in the healthiest and most efficient way.

Is PrEP right for me?

The CDC suggests that PrEP is an excellent option for people who are: weigh at least 77 pounds (35kg), are currently HIV-negative, and meet one or more of the following criteria:

  • In a sexual relationship with someone who is living with HIV, especially when they are not undetectable
  • In a sexual relationship with a partner or multiple partners, with an unknown HIV status
  • One or more incidences of anal or vaginal sex without a condom in the last 6 months
  • Diagnosis of gonorrhea, chlamydia, or syphilis in the last 6 months
  • Inject drugs not prescribed by a medical provider or share works for drug preparation
  • Have a partner living with detectable HIV

PrEP will not be a good option for those who meet any of the following:

  • Are already living with HIV. Truvada® for PrEP is not enough to treat HIV.
  • Who have symptoms of acute HIV infection or have been exposed to HIV in the last 72 hours (PEP may be a better option).
  • Diagnosed with Hepatitis B. Truvada® can also be used as an option for Hepatitis B treatment, but a primary care provider will need to evaluate you for proper care.
  • Diagnosed with uncontrollable diabetes or impaired kidney function.

What lab work do I need to do?

Before you can start Truvada® for PrEP, you will need to complete lab work. After you get started on PrEP, you will only need to get your labs done every 3 months.

We know getting labs done isn’t the most enjoyable process, but it’s important to know your status and it will help keep you and your partner(s) healthy.

We even offer lab work options that can be done in the comfort and privacy of your own home. You will be tested for: You will be tested for:

  • HIV
  • Kidney function (creatinine)
  • Hepatitis B
  • Gonorrhea, chlamydia, and syphilis (optional, but we highly recommend this)
  • Pregnancy (for female-bodied patients)

How quickly does PrEP start working?

When taken daily, PrEP is safe and highly effective in preventing HIV. PrEP reaches maximum effectiveness for receptive anal sex (bottoming) after about 7 days.

For all other activities, including insertive anal sex (being the top) and vaginal sex, PrEP reaches maximum effectiveness after about 21 days.

How old do I need to be to start taking PrEP?

Based on FDA requirements, PrEP users should be at least 77 pounds. Age limits are only considered when state-specific laws require it. If you are a minor and are interested in PrEP, please don’t hesitate to contact us.


Getting your first PrEP prescription, and getting refills every three months, requires lab testing. To ensure you’re eligible for PrEP, you will be tested for:

HIV: PrEP is only beneficial for those who are currently not living with HIV.

Kidney Function: Because medications like Truvada can sometimes add strain to your kidneys, we test blood creatinine levels to ensure your kidneys are staying healthy.

Hepatitis B: Truvada can also interact with the hepatitis B virus (HBV), so we’ll want to provide some additional medical oversight to ensure you don’t have any negative interactions.

Pregnancy: Though PrEP is safe to use during pregnancy, we always refer pregnant women to their OB/GYN.

STIs: We screen for gonorrhea, chlamydia and syphilis, curable infections that benefit from early treatment.

For more information, Please visit NURX


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Written by STDsSTIs

STDsSTIs is here to help people think, discuss and take responsible action on some of life’s biggest decisions – ones that often don’t get enough attention. We help raise the tough questions and ask young people to consider what really makes sense for them. Together, we can help Coloradans lead healthier lives and raise healthier families.

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